Metformin hydrochloride(also called Glucophage) is a prescription medicine licensed for the treatment of type 2 diabetes. It can help lower blood sugar levels by decreasing the amount of sugar made by the liver and the amount of sugar absorbed into the body from the diet.
The medication comes in a tablet form, two long-acting forms, and a liquid version. These products are taken by mouth, usually one to three times a day.
May be used in combination with a sulfonylurea, repaglinide, or thiazolidinedione antidiabetic agent for the management of type 2 diabetes mellitusin patients who do not achieve adequate glycemic control on monotherapy with Metformin hydrochloride or any of these drugs.
May be used with insulin to improve glycemic control and/or decrease the required dosage of insulin.
Commercially available in fixed combination with glyburide or glipizide for use as an adjunct to diet and exercise in adults with type 2 diabetes mellitus. May add a thiazolidinedione antidiabetic agent if patient has inadequate glycemic control with fixed-combination metformin/glyburide therapy.
Commercially available in fixed combination with rosiglitazone for use when treatment with both rosiglitazone and metformin is appropriate. Use of metformin/rosiglitazone (Avandamet) is restricted to patients who are already being treated successfully with rosiglitazone and to those not already receiving rosiglitazone who are unable to achieve glycemic control with other antidiabetic agents and have decided (in consultation with their healthcare provider) not to take pioglitazone-containing preparations for medical reasons.
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